Abstract
We conducted a population-based case-control study in Connecticut women to test the hypothesis that genetic variations in DNA repair pathway genes may modify the relationship between body mass index (BMI) and risk of non-Hodgkin lymphoma (NHL). Compared to those with BMI <25, women with BMI ≥25 had significantly increased risk of NHL among women who carried BRCA1 (rs799917) CT/TT, ERCC2 (rs13181) AA, XRCC1 (rs1799782) CC, and WRN (rs1801195) GG genotypes, but no increase in NHL risk among women who carried BRCA1 CC, ERCC2 AC/CC, XRCC1 CT/TT, and WRN GT/TT genotypes. A significant interaction with BMI was only observed for WRN (rs1801195; P = 0.004) for T-cell lymphoma and ERCC2 (rs13181; P = 0.002) for diffuse large B-cell lymphoma. The results suggest that common genetic variation in DNA repair pathway genes may modify the association between BMI and NHL risk.
Copyright © 2013 Wiley Periodicals, Inc.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, N.I.H., Intramural
MeSH terms
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Adult
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Aged
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Aged, 80 and over
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Body Mass Index*
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Case-Control Studies
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DNA Repair*
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DNA-Binding Proteins / genetics
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Exodeoxyribonucleases / genetics*
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Female
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Genotype
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Humans
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Lymphoma, Large B-Cell, Diffuse / diagnosis
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Lymphoma, Large B-Cell, Diffuse / genetics*
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Lymphoma, Large B-Cell, Diffuse / pathology
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Lymphoma, Non-Hodgkin / diagnosis
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Lymphoma, Non-Hodgkin / genetics*
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Lymphoma, Non-Hodgkin / pathology
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Middle Aged
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Polymorphism, Genetic*
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RecQ Helicases / genetics*
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Risk Factors
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Ubiquitin-Protein Ligases / genetics
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Werner Syndrome Helicase
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X-ray Repair Cross Complementing Protein 1
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Xeroderma Pigmentosum Group D Protein / genetics*
Substances
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DNA-Binding Proteins
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X-ray Repair Cross Complementing Protein 1
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XRCC1 protein, human
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BRAP protein, human
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Ubiquitin-Protein Ligases
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Exodeoxyribonucleases
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RecQ Helicases
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WRN protein, human
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Werner Syndrome Helicase
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Xeroderma Pigmentosum Group D Protein
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ERCC2 protein, human