Roles of NLRP10 in innate and adaptive immunity

Anna Damm; Katja Lautz; Thomas A Kufer

doi:10.1016/j.micinf.2013.03.008

Roles of NLRP10 in innate and adaptive immunity

Microbes Infect. 2013 Jun;15(6-7):516-23. doi: 10.1016/j.micinf.2013.03.008. Epub 2013 Apr 4.

Authors

Anna Damm¹, Katja Lautz, Thomas A Kufer

Affiliation

¹ Institute for Medical Microbiology, Immunology and Hygiene, University of Cologne, 50931 Cologne, Germany.

PMID: 23562614
DOI: 10.1016/j.micinf.2013.03.008

Abstract

Mammalian nucleotide-binding domain leucine-rich repeat containing proteins (NLRs) are important pattern-recognition receptors, still the function of many NLRs remains poorly defined. Here we review first insights into the molecular function of NLRP10 highlighting the role of this specific NLR in innate and adaptive immune responses.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Adaptive Immunity*
Adaptor Proteins, Signal Transducing
Animals
Apoptosis Regulatory Proteins / immunology*
Apoptosis Regulatory Proteins / metabolism*
Carrier Proteins / immunology*
Carrier Proteins / metabolism*
Humans
Immunity, Innate*
Inflammation / immunology
Inflammation / metabolism
Mice

Substances

Adaptor Proteins, Signal Transducing
Apoptosis Regulatory Proteins
Carrier Proteins
NLRP10 protein, human
NLRP10 protein, mouse