Exonic resequencing of the DLGAP3 gene as a candidate gene for schizophrenia

Jun-Ming Li; Chao-Lin Lu; Min-Chih Cheng; Sy-Ueng Luu; Shih-Hsin Hsu; Chia-Hsiang Chen

doi:10.1016/j.psychres.2012.12.015

Exonic resequencing of the DLGAP3 gene as a candidate gene for schizophrenia

Psychiatry Res. 2013 Jun 30;208(1):84-7. doi: 10.1016/j.psychres.2012.12.015. Epub 2013 Feb 13.

Authors

Jun-Ming Li¹, Chao-Lin Lu, Min-Chih Cheng, Sy-Ueng Luu, Shih-Hsin Hsu, Chia-Hsiang Chen

Affiliation

¹ Department of Psychiatry, Taoyuan Armed Forces General Hospital, Taoyuan, Taiwan.

PMID: 23414653
DOI: 10.1016/j.psychres.2012.12.015

Abstract

We resequenced the exonic regions of the DLGAP3 gene, which encodes SAP90/PSD95-associated protein 3, in 215 schizophrenic patients and 215 non-psychotic controls. Seven known single-nucleotide polymorphisms (SNPs) were identified, but not associated with schizophrenia. Nevertheless, we identified several rare missense mutations and some of them might be associated with the pathogenesis of schizophrenia.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Asian People / genetics
Exons / genetics*
Female
Genetic Association Studies*
Genetic Predisposition to Disease / genetics*
Genotype
Humans
Male
Middle Aged
Mutation, Missense / genetics
Nerve Tissue Proteins / genetics*
Polymorphism, Single Nucleotide / genetics
Schizophrenia / genetics*

Substances

DLGAP3 protein, human
Nerve Tissue Proteins