[CCR5, CCR2, apoe, p53, ITGB3 and HFE gene polymorphism in Western Siberia long-livers]

Adv Gerontol. 2012;25(3):394-7.
[Article in Russian]

Abstract

In order to estimate the distribution of some polymorphisms for the CCR5, CCR2, apoE, p53, ITGB3, and HFE genes in Russian long-livers from Western Siberia, a sample of 271 individuals (range 90-105 years) was examined. It was demonstrated that carriage of the delta32 polymorphism for the CCR5 gene, V64/polymorphism for the CCR2 gene, e2/e3/e4 for the apoE gene, L33P for the ITGB3 gene, as well as H63D and S65C polymorphisms for the HFE gene does not influence on predisposition to the longevity; carriage of the 282 Y allele for the HFE gene negatively influences on the longevity; carriage of the heterozygous genotype for the R72P polymorphism for the p53 gene correlates with the longevity of elderly people.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Alleles
  • Apolipoproteins E / genetics*
  • DNA / genetics
  • Gene Frequency
  • Genes, p53 / genetics*
  • Genotype
  • Hemochromatosis Protein
  • Histocompatibility Antigens Class I / genetics*
  • Humans
  • Integrin beta3 / genetics*
  • Longevity / genetics*
  • Male
  • Membrane Proteins / genetics*
  • Middle Aged
  • Polymerase Chain Reaction
  • Polymorphism, Genetic*
  • Receptors, CCR5 / genetics*
  • Siberia

Substances

  • Apolipoproteins E
  • HFE protein, human
  • Hemochromatosis Protein
  • Histocompatibility Antigens Class I
  • ITGB3 protein, human
  • Integrin beta3
  • Membrane Proteins
  • Receptors, CCR5
  • DNA