Abstract
We compared the cell membrane (CM) lipid composition among nine well-characterized daptomycin-susceptible (Dap(s))/Dap-resistant (Dap(r)) methicillin-resistant Staphylococcus aureus (MRSA) strain pairs. Compared to the 9 Dap(s) parental strains, Dap(r) strains (with or without mprF-yycFG mutations) exhibited significantly reduced phosphatidylglycerol (PG) content (P < 0.01), significantly increased total synthesis of lysyl-PG (LPG) (P < 0.01), and reduced carotenoid content (P < 0.05 for 5/9 strains). There were no significant changes in LPG flipping, cardiolipin content, or fatty acid composition among strain pairs.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Aminoacyltransferases / genetics
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Anti-Bacterial Agents / pharmacology*
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Bacterial Proteins / genetics
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Cardiolipins / metabolism
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Carotenoids / metabolism
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Cell Membrane / metabolism
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Daptomycin / pharmacology*
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Fatty Acids / metabolism
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Lysine / metabolism
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Membrane Lipids / metabolism*
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Methicillin-Resistant Staphylococcus aureus / drug effects*
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Methicillin-Resistant Staphylococcus aureus / metabolism*
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Microbial Sensitivity Tests
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Phosphatidylglycerols / metabolism
Substances
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Anti-Bacterial Agents
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Bacterial Proteins
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Cardiolipins
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Fatty Acids
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Membrane Lipids
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Phosphatidylglycerols
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YycF protein, Bacteria
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Carotenoids
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lysylphosphatidylglycerol
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Aminoacyltransferases
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mprF protein, Staphylococcus aureus
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Lysine
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Daptomycin