Abstract
Antistaphylococcal agents commonly lack activity against Gram-negative bacteria like Escherichia coli owing to the permeability barrier presented by the outer membrane and/or the action of efflux transporters. When these intrinsic resistance mechanisms are artificially compromised, such agents almost invariably demonstrate antibacterial activity against Gram negatives. Here we show that this is not the case for the antibiotic daptomycin, whose target appears to be absent from E. coli and other Gram-negative pathogens.
MeSH terms
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Anti-Bacterial Agents / pharmacology*
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Cell Membrane / drug effects
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Cell Membrane / metabolism
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Cell Membrane Permeability / drug effects
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Daptomycin / pharmacology*
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Enterobacter cloacae / drug effects
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Enterobacter cloacae / growth & development
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Enterobacter cloacae / metabolism
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Escherichia coli / drug effects*
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Escherichia coli / growth & development
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Escherichia coli / metabolism
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Klebsiella pneumoniae / drug effects
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Klebsiella pneumoniae / growth & development
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Klebsiella pneumoniae / metabolism
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Microbial Sensitivity Tests
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Moraxella catarrhalis / drug effects
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Moraxella catarrhalis / growth & development
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Moraxella catarrhalis / metabolism
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Pseudomonas aeruginosa / drug effects
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Pseudomonas aeruginosa / growth & development
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Pseudomonas aeruginosa / metabolism
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Salmonella typhimurium / drug effects
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Salmonella typhimurium / growth & development
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Salmonella typhimurium / metabolism
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Species Specificity
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Staphylococcus aureus / drug effects*
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Staphylococcus aureus / growth & development
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Staphylococcus aureus / metabolism
Substances
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Anti-Bacterial Agents
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Daptomycin