Expression of splice variants of cancer-testis genes ODF3 and ODF4 in the testis of a prostate cancer patient

Genet Mol Res. 2012 Oct 4;11(4):3642-8. doi: 10.4238/2012.October.4.11.

Abstract

The outer dense fiber (ODF) genes encode proteins that co-assemble along the axoneme of the sperm tail. Recently, it was demonstrated that some ODF genes are aberrantly expressed in tumors, including prostate adenocarcinoma, basal cell carcinoma, and chronic myeloid lymphoma. We cloned ODF3 and ODF4 cDNA from the testis of a patient suffering from prostate adenocarcinoma and found two alternative splice variants of these genes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alternative Splicing / genetics*
  • Base Sequence
  • Exons / genetics
  • Gene Expression Regulation, Neoplastic*
  • Humans
  • Male
  • Molecular Sequence Data
  • Open Reading Frames / genetics
  • Prostatic Neoplasms / genetics*
  • Reverse Transcriptase Polymerase Chain Reaction
  • Seminal Plasma Proteins / genetics*
  • Seminal Plasma Proteins / metabolism
  • Sequence Analysis, DNA
  • Testis / metabolism*
  • Testis / pathology

Substances

  • ODF3 protein, human
  • ODF4 protein, human
  • Seminal Plasma Proteins