Contribution of the OATP1B subfamily to cancer biology and treatment

Clin Pharmacol Ther. 2012 Nov;92(5):658-60. doi: 10.1038/clpt.2012.127. Epub 2012 Sep 26.

Abstract

The organic anion transporter 1B (OATP1B) subfamily consists of OATP1B1 and OATP1B3. These transporters have generally been considered liver-specific; however, recent evidence demonstrates that they are also expressed in extrahepatic tissues and in some tumors. This review discusses the potential influence of extrahepatic OATP1B expression on homeostasis and pathophysiology and its implications for pharmacotherapy in general.

Publication types

  • Review

MeSH terms

  • Gene Expression Regulation
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Liver / metabolism
  • Liver-Specific Organic Anion Transporter 1
  • Neoplasms / genetics
  • Neoplasms / pathology*
  • Neoplasms / therapy
  • Organic Anion Transporters / genetics
  • Organic Anion Transporters / metabolism*
  • Organic Anion Transporters, Sodium-Independent / genetics
  • Organic Anion Transporters, Sodium-Independent / metabolism*
  • Solute Carrier Organic Anion Transporter Family Member 1B3

Substances

  • Liver-Specific Organic Anion Transporter 1
  • Organic Anion Transporters
  • Organic Anion Transporters, Sodium-Independent
  • SLCO1B1 protein, human
  • SLCO1B3 protein, human
  • Solute Carrier Organic Anion Transporter Family Member 1B3