Abstract
The organic anion transporter 1B (OATP1B) subfamily consists of OATP1B1 and OATP1B3. These transporters have generally been considered liver-specific; however, recent evidence demonstrates that they are also expressed in extrahepatic tissues and in some tumors. This review discusses the potential influence of extrahepatic OATP1B expression on homeostasis and pathophysiology and its implications for pharmacotherapy in general.
MeSH terms
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Gene Expression Regulation
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Gene Expression Regulation, Neoplastic
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Humans
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Liver / metabolism
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Liver-Specific Organic Anion Transporter 1
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Neoplasms / genetics
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Neoplasms / pathology*
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Neoplasms / therapy
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Organic Anion Transporters / genetics
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Organic Anion Transporters / metabolism*
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Organic Anion Transporters, Sodium-Independent / genetics
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Organic Anion Transporters, Sodium-Independent / metabolism*
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Solute Carrier Organic Anion Transporter Family Member 1B3
Substances
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Liver-Specific Organic Anion Transporter 1
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Organic Anion Transporters
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Organic Anion Transporters, Sodium-Independent
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SLCO1B1 protein, human
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SLCO1B3 protein, human
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Solute Carrier Organic Anion Transporter Family Member 1B3