[Remodeling of the cardiovascular system and development of chronic kidney disease in patients with metabolic syndrome and obesity: role of eNOS, subunit p22-phox of NADPH-oxidase and MTHFR genes]

Ter Arkh. 2012;84(6):26-31.
[Article in Russian]

Abstract

Aim: To examine contribution of polymorphisms of genes of endothelial NO-synthase (eNOS), NADPH-oxidase and methylenetetrahydrofolate reductase (mTHFR) to development of remodeling of cardiovascular system and chronic disease of the kidneys (CDK) in patients with metabolic syndrome (mS) and obesity. MATERIAL AND METHODS. Standard clinical and device examinations were made and polymorphisms C242T of gene of subunit p22-phox of NADPH-oxidase, G894T of gene of eNOS and C677T of gene of MTHFR were studied in 66 MS patients (49 males and 17 females, age 19-62 years.

Results: The presence of even one prognostically poor allele variants of the genes studied was registered in 83 examinees. The genotype 242TTp22-phox of NADPH-oxidase subunit was associated with the highest insulin resistance, allele 894T of gene eNOS- with reduced glomerular filtration rate and progression of left ventricular hypertrophy.

Conclusion: Polymorphism of the genes the products of which modulate endothelial function can be considered as potential predictors of severity of MS target organs impairment.

MeSH terms

  • Adult
  • Endothelium, Vascular / enzymology
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Humans
  • Hypertrophy, Left Ventricular / diagnosis
  • Hypertrophy, Left Ventricular / enzymology
  • Hypertrophy, Left Ventricular / etiology*
  • Hypertrophy, Left Ventricular / genetics
  • Male
  • Metabolic Syndrome / complications*
  • Metabolic Syndrome / diagnosis
  • Metabolic Syndrome / enzymology
  • Metabolic Syndrome / genetics
  • Methylenetetrahydrofolate Reductase (NADPH2) / genetics*
  • Middle Aged
  • NADPH Oxidases / genetics*
  • Nitric Oxide Synthase Type III / genetics*
  • Obesity / complications*
  • Obesity / diagnosis
  • Obesity / enzymology
  • Obesity / genetics
  • Polymerase Chain Reaction
  • Polymorphism, Restriction Fragment Length
  • Predictive Value of Tests
  • Renal Insufficiency, Chronic / diagnosis
  • Renal Insufficiency, Chronic / enzymology
  • Renal Insufficiency, Chronic / etiology*
  • Renal Insufficiency, Chronic / genetics
  • Severity of Illness Index
  • Ventricular Remodeling / genetics
  • Young Adult

Substances

  • NOS3 protein, human
  • Nitric Oxide Synthase Type III
  • MTHFR protein, human
  • Methylenetetrahydrofolate Reductase (NADPH2)
  • NADPH Oxidases
  • CYBA protein, human