Expression of TLR9 and BD-2 protein genes in corneal cells of mice of different strains with herpetic keratitis

V A Chereshnev; L V Gankovskaya; L V Koval'chuk; M V Chereshneva; O A Gankovskaya; T V Gavrilova

doi:10.1007/s10517-012-1685-9

Expression of TLR9 and BD-2 protein genes in corneal cells of mice of different strains with herpetic keratitis

Bull Exp Biol Med. 2012 Jun;153(2):236-9. doi: 10.1007/s10517-012-1685-9.

[Article in English, Russian]

Authors

V A Chereshnev¹, L V Gankovskaya, L V Koval'chuk, M V Chereshneva, O A Gankovskaya, T V Gavrilova

Affiliation

¹ Institute of Immunology and Physiology, Ural Division of the Russian Academy of Sciences, Ekaterinburg, Russia.

PMID: 22816092
DOI: 10.1007/s10517-012-1685-9

Abstract

The dynamics of gene expression of two proteins, TLR9 (one of the key receptors recognizing CpG repeats of herpes virus DNA) and β-defensin 2 (antibacterial peptide), was studied on the model of herpetic keratitis in C57Bl/6 and BALB/c mice. New data on differences in TLR9 gene expression in mice of the two strains infected with the virus were obtained. Reduced TLR9 gene expression in the cornea of C57Bl/6 mice was associated with their high sensitivity to infection caused by herpes simplex 1 virus.

MeSH terms

Amino Acid Sequence
Animals
Cornea / immunology
Cornea / metabolism*
Cornea / virology
Gene Expression*
Herpes Simplex
Immunity, Innate
Keratitis, Herpetic / genetics*
Keratitis, Herpetic / immunology*
Keratitis, Herpetic / metabolism
Keratitis, Herpetic / virology
Male
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Molecular Sequence Data
RNA, Messenger / genetics
RNA, Messenger / metabolism
Toll-Like Receptor 9 / chemistry
Toll-Like Receptor 9 / genetics*
Toll-Like Receptor 9 / metabolism
beta-Defensins / genetics*
beta-Defensins / metabolism

Substances

RNA, Messenger
Tlr9 protein, mouse
Toll-Like Receptor 9
beta-Defensins