Role of polymorphic variants of MTR gene A2756G and SHMT1 gene C1420T in the development of prostatic cancer in residents of the Western Siberian Region of Russia

A S Weiner; N A Oskina; A F Lacarev; V D Petrova; D I Ganov; U A Boyarskih; O G Tonacheva; E N Voronina; M L Filipenko

doi:10.1007/s10517-012-1554-6

Role of polymorphic variants of MTR gene A2756G and SHMT1 gene C1420T in the development of prostatic cancer in residents of the Western Siberian Region of Russia

Bull Exp Biol Med. 2012 Feb;152(4):466-9. doi: 10.1007/s10517-012-1554-6.

[Article in English, Russian]

Authors

A S Weiner¹, N A Oskina, A F Lacarev, V D Petrova, D I Ganov, U A Boyarskih, O G Tonacheva, E N Voronina, M L Filipenko

Affiliation

¹ Institute of Chemical Biology and Basic Medicine, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia. hamlet85@yandex.ru

PMID: 22803112
DOI: 10.1007/s10517-012-1554-6

Abstract

Allelic variants of folate cycle enzyme genes can contribute to predisposition to cancer. The impact of polymorphic loci A2756G of MTR gene and of C1420T of SHMT1 gene for the risk of prostatic cancer was studied in residents of West Siberia. The frequency of alleles of these loci in patients (N=371) and controls (N=285) was determined and the data were statistically processed. No statistically significant association with prostatic cancer was detected for any of the studied loci.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase / genetics*
Adult
Aged
Alleles
Case-Control Studies
Folic Acid / metabolism
Gene Frequency
Genetic Loci
Genotype
Glycine Hydroxymethyltransferase / genetics*
Humans
Male
Middle Aged
Polymorphism, Single Nucleotide*
Prostatic Neoplasms / genetics*
Risk Factors
Siberia
White People / genetics*

Substances

Folic Acid
5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase
Glycine Hydroxymethyltransferase
SHMT protein, human