Involvement of transforming growth factor β and its type 1 receptor in the development of breast cancer

V V Keshelava; O S Khodorovich; G O Shaykhaev; N L Chazova; A M Bereschanskaya

doi:10.1007/s10517-011-1464-z

Involvement of transforming growth factor β and its type 1 receptor in the development of breast cancer

Bull Exp Biol Med. 2011 Nov;152(1):98-100. doi: 10.1007/s10517-011-1464-z.

[Article in English, Russian]

Authors

V V Keshelava¹, O S Khodorovich, G O Shaykhaev, N L Chazova, A M Bereschanskaya

Affiliation

¹ Russian Research Center of Radiology, Moscow, Russia.

PMID: 22803051
DOI: 10.1007/s10517-011-1464-z

Abstract

Introduction of recent achievements of molecular biology into clinical practice contributes significantly to both prevention and early detection of breast cancer in women and development of new approaches, including genotyping, to screening for breast cancer. Screening for genetic polymorphisms in genes TGFβ1 and TGFβR1 reveals carriers of sporadic breast cancer. This provides an opportunity to reassess the role and place of preventive measures, also including surgical method, in the fight against breast cancer.

MeSH terms

Adolescent
Adult
Aged
Breast Neoplasms / genetics*
Breast Neoplasms / pathology
Calcinosis / genetics*
Calcinosis / pathology
DNA Mutational Analysis
Female
Humans
Middle Aged
Polymorphism, Genetic
Protein Serine-Threonine Kinases / genetics*
Receptor, Transforming Growth Factor-beta Type I
Receptors, Transforming Growth Factor beta / genetics*
Transforming Growth Factor beta1 / genetics*
Young Adult

Substances

Receptors, Transforming Growth Factor beta
Transforming Growth Factor beta1
Protein Serine-Threonine Kinases
Receptor, Transforming Growth Factor-beta Type I