Innate immunity's path to the Nobel Prize 2011 and beyond

Eur J Immunol. 2012 May;42(5):1089-92. doi: 10.1002/eji.201242404.

Abstract

The 2011 Nobel Prize in Physiology/Medicine to Ralph Steinmann, Jules Hoffmann, and Bruce Beutler recognized a paradigm shift in our understanding of innate immunity, and its impact on adaptive immunity. The Prize highlighted the initial discoveries of Toll's role in immunity in flies, Toll-like receptors in mammals, and the establishment of dendritic cells as the initiators of adaptive immunity. This historical Commentary focuses on the developments in our understanding of innate immunity.

Publication types

  • Historical Article

MeSH terms

  • Allergy and Immunology / history*
  • Animals
  • Dendritic Cells / immunology
  • History, 20th Century
  • History, 21st Century
  • Humans
  • Immunity, Innate / immunology*
  • Mice
  • Nobel Prize*
  • Toll-Like Receptors / history*
  • Toll-Like Receptors / immunology

Substances

  • Toll-Like Receptors