Role of cathepsin A and cathepsin C in the regulation of glycosidase activity

Alina Minarowska; Łukasz Minarowski; Alicja Karwowska; Anna Justyna Milewska; Marek Gacko

doi:10.2478/18692

Role of cathepsin A and cathepsin C in the regulation of glycosidase activity

Folia Histochem Cytobiol. 2012 Apr 24;50(1):20-4. doi: 10.2478/18692.

Authors

Alina Minarowska¹, Łukasz Minarowski, Alicja Karwowska, Anna Justyna Milewska, Marek Gacko

Affiliation

¹ Department of Lung Diseases and Tuberculosis, Medical University of Bialystok, Poland.

PMID: 22532132
DOI: 10.2478/18692

Abstract

Increased tissue activity of cathepsin A and cathepsin C can be observed in many pathological conditions. It is associated with an enhanced degradation of glycosaminoglycans, proteoglycans, and glycoproteins, and results in their decreased tissue content. Cathepsin C releases the glycosidases from complexes formed with cathepsin A, and reinstates their activity. In this review a current state of knowledge is presented concerning the regulation of selected glycosidases activity by cathepsin A (EC 3.4.16.1) and C (EC 3.4.14.1).

Publication types

Review

MeSH terms

Amino Acid Sequence
Cathepsin A / metabolism*
Cathepsin C / metabolism*
Glycoside Hydrolases / metabolism*
Humans
Models, Molecular
Molecular Sequence Data

Substances

Glycoside Hydrolases
Cathepsin C
Cathepsin A