Structure of a mouse histone-encoding gene cluster

Gene. 1990 Nov 15;95(2):303-4. doi: 10.1016/0378-1119(90)90377-4.

Abstract

In addition to a previously described histone (H)-encoding H4 gene [Meier et al., Nucleic Acids Res. 17 (1989) 795], the mouse genomic DNA clone 53 contains two H3 genes, one functional and one partially deleted H2A gene, and one H2B gene. Clone 53 overlaps for 3 kb with MH143, another previously isolated mouse H-encoding clone [Yang et al., J. Biol. Chem. 262 (1987) 17118-17125], thus defining a 32-kb region of mouse chromosome 13 with a total of seven H-encoding genes. We have determined the nucleotide sequences and transcription start points of two genes coding for the H2A.1 and H3.2 proteins.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Histones / genetics*
  • Mice
  • Molecular Sequence Data
  • Multigene Family*
  • Restriction Mapping
  • Transcription, Genetic

Substances

  • Histones

Associated data

  • GENBANK/M33988
  • GENBANK/M33989