Abstract
Potential emergence of enterococcal daptomycin nonsusceptibility among patients with no prior exposure to daptomycin poses clinical and public health challenges. We found that development of infections with daptomycin-nonsusceptible enterococci in these patients could be associated with sporadic emergence and clonal spread.
MeSH terms
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Adult
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Aged
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Anti-Bacterial Agents / pharmacology*
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Anti-Bacterial Agents / therapeutic use
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Daptomycin / pharmacology*
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Daptomycin / therapeutic use
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Drug Resistance, Multiple, Bacterial*
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Enterococcus faecalis / drug effects*
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Enterococcus faecalis / isolation & purification
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Enterococcus faecium / drug effects*
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Enterococcus faecium / isolation & purification
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Female
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Gram-Positive Bacterial Infections / drug therapy*
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Gram-Positive Bacterial Infections / microbiology
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Gram-Positive Bacterial Infections / mortality
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Humans
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Male
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Microbial Sensitivity Tests
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Middle Aged
Substances
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Anti-Bacterial Agents
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Daptomycin