Calcium signalling remodelling and disease

Biochem Soc Trans. 2012 Apr;40(2):297-309. doi: 10.1042/BST20110766.

Abstract

A wide range of Ca2+ signalling systems deliver the spatial and temporal Ca2+ signals necessary to control the specific functions of different cell types. Release of Ca2+ by InsP3 (inositol 1,4,5-trisphosphate) plays a central role in many of these signalling systems. Ongoing transcriptional processes maintain the integrity and stability of these cell-specific signalling systems. However, these homoeostatic systems are highly plastic and can undergo a process of phenotypic remodelling, resulting in the Ca2+ signals being set either too high or too low. Such subtle dysregulation of Ca2+ signals have been linked to some of the major diseases in humans such as cardiac disease, schizophrenia, bipolar disorder and Alzheimer's disease.

Publication types

  • Review

MeSH terms

  • Buffers
  • Calcium Channels / metabolism
  • Calcium Signaling*
  • Disease*
  • Humans
  • Phenotype
  • Receptors, Cell Surface / metabolism

Substances

  • Buffers
  • Calcium Channels
  • Receptors, Cell Surface