Multiple modes of cytoplasmic dynein regulation

Nat Cell Biol. 2012 Feb 29;14(3):224-30. doi: 10.1038/ncb2420.

Abstract

In performing its multiple cellular functions, the cytoplasmic dynein motor is subject to complex regulation involving allosteric mechanisms within the dynein complex, as well as numerous extramolecular interactions controlling subcellular targeting and motor activity. Recent work has distinguished high- and low-load regulatory modes for cytoplasmic dynein, which, combined with a diversity of targeting mechanisms, accounts for a very broad range of functions.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • 1-Alkyl-2-acetylglycerophosphocholine Esterase / metabolism*
  • Animals
  • Biological Transport
  • Carrier Proteins / metabolism*
  • Cytoplasmic Dyneins / chemistry
  • Cytoplasmic Dyneins / metabolism*
  • Dynactin Complex
  • Humans
  • Microtubule-Associated Proteins / metabolism*
  • Models, Biological
  • Protein Binding
  • Protein Multimerization

Substances

  • Carrier Proteins
  • DYNC1H1 protein, human
  • Dynactin Complex
  • Microtubule-Associated Proteins
  • NDEL1 protein, human
  • 1-Alkyl-2-acetylglycerophosphocholine Esterase
  • PAFAH1B1 protein, human
  • Cytoplasmic Dyneins