Type I interferon pathway in adult and juvenile dermatomyositis

Emily C Baechler; Hatice Bilgic; Ann M Reed

doi:10.1186/ar3531

Type I interferon pathway in adult and juvenile dermatomyositis

Arthritis Res Ther. 2011;13(6):249. doi: 10.1186/ar3531. Epub 2011 Dec 22.

Authors

Emily C Baechler¹, Hatice Bilgic, Ann M Reed

Affiliation

¹ Division of Rheumatic and Autoimmune Diseases, Department of Medicine, University of Minnesota, Minneapolis, MN 55455, USA.

PMID: 22192711
PMCID: PMC3334651
DOI: 10.1186/ar3531

Abstract

Gene expression profiling and protein studies of the type I interferon pathway have revealed important insights into the disease process in adult and juvenile dermatomyositis. The most prominent and consistent feature has been a characteristic whole blood gene signature indicating upregulation of the type I interferon pathway. Upregulation of the type I interferon protein signature has added additional markers of disease activity and insight into the pathogenesis of the disease.

Publication types

Review

MeSH terms

Adult
Child
Dermatomyositis / blood
Dermatomyositis / genetics*
Dermatomyositis / pathology
Gene Expression Profiling
Humans
Interferon Type I / blood
Interferon Type I / genetics*
Interferon-alpha / blood
Interferon-alpha / genetics*
Interferon-beta / blood
Interferon-beta / genetics*
Signal Transduction / genetics*
Up-Regulation

Substances

Interferon Type I
Interferon-alpha
interferon omega 1
Interferon-beta

Supplementary concepts

Amyopathic dermatomyositis