IDEAL spiral CSI for dynamic metabolic MR imaging of hyperpolarized [1-13C]pyruvate

Magn Reson Med. 2012 Jul;68(1):8-16. doi: 10.1002/mrm.23212. Epub 2011 Nov 29.

Abstract

Metabolic imaging with hyperpolarized [1-(13)C]pyruvate offers the unique opportunity for a minimally invasive detection of cellular metabolism. Efficient and robust acquisition and reconstruction techniques are required for capturing the wealth of information present for the limited duration of the hyperpolarized state (~1 min). In this study, the Dixon/IDEAL type of water-fat separation is expanded toward spectroscopic imaging of [1-(13) C]pyruvate and its down-stream metabolites. For this purpose, the spectral-spatial encoding is based on single-shot spiral image encoding and echo-time shifting in between excitations for the chemical-shift encoding. In addition, also a free-induction decay spectrum is acquired and the obtained chemical-shift prior knowledge is efficiently used in the reconstruction. The spectral-spatial reconstruction problem is found to efficiently separate into a chemical-shift inversion followed by a spatial reconstruction. The method is successfully demonstrated for dynamic, multislice [1-(13)C]pyruvate metabolic MR imaging in phantom and in vivo rat experiments.

MeSH terms

  • Administration, Inhalation
  • Algorithms*
  • Animals
  • Carbon Isotopes / administration & dosage
  • Carbon Isotopes / analysis
  • Carbon Isotopes / pharmacokinetics
  • Kidney / metabolism*
  • Magnetic Resonance Imaging / methods*
  • Magnetic Resonance Spectroscopy / methods*
  • Metabolic Clearance Rate
  • Myocardium / metabolism*
  • Organ Specificity
  • Pyruvic Acid / administration & dosage
  • Pyruvic Acid / analysis
  • Pyruvic Acid / pharmacokinetics*
  • Rats
  • Tissue Distribution

Substances

  • Carbon Isotopes
  • Pyruvic Acid