The mas oncogene as a neural peptide receptor: expression, regulation and mechanism of action

Ciba Found Symp. 1990:150:23-38; discussion 38-46. doi: 10.1002/9780470513927.ch3.

Abstract

The human mas oncogene, which renders transfected NIH/3T3 cells tumorigenic, was identified as a subtype of angiotensin receptor by transient expression in Xenopus oocytes and stable expression in the mammalian neuronal cell line, NG115-401L. The mas receptor preferentially recognizes angiotensin III, and is expressed at high levels in brain. The mas/angiotensin receptor functions through the breakdown of inositol lipids and can drive DNA synthesis, unlike another inositol-linked peptide receptor, that for bradykinin. Comparative analysis of several early biochemical events elicited by either angiotensin or bradykinin stimulation of mas-transfected cells has not indicated a specific difference correlated with mitogenic activity. In particular, the inositol lipid kinase, phosphatidylinositol-3-kinase, thought to be involved in the mitogenic mechanism of platelet-derived growth factor receptors, is unaffected by activation of mas. These results have shown that a proto-oncogene encodes a neural peptide receptor, indicating that peptide receptors may be involved in differentiation and proliferation processes, as are other identified proto-oncogenes.

Publication types

  • Review

MeSH terms

  • Amino Acid Sequence
  • Angiotensin III / metabolism
  • Animals
  • Brain / metabolism*
  • Gene Expression Regulation*
  • Humans
  • Molecular Sequence Data
  • Oncogenes*
  • Protein Conformation
  • Proto-Oncogene Mas
  • Proto-Oncogenes*
  • Receptors, Angiotensin / genetics*
  • Transfection

Substances

  • MAS1 protein, human
  • Proto-Oncogene Mas
  • Receptors, Angiotensin
  • Angiotensin III