Abstract
The organization and function of eukaryotic cells rely on the action of many different molecular motor proteins. Cytoplasmic dynein drives the movement of a wide range of cargoes towards the minus ends of microtubules, and these events are needed, not just at the single-cell level, but are vital for correct development. In the present paper, I review recent progress on understanding dynein's mechanochemistry, how it is regulated and how it binds to such a plethora of cargoes. The importance of a number of accessory factors in these processes is discussed.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Biological Transport / physiology
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Cytoplasmic Dyneins / chemistry
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Cytoplasmic Dyneins / genetics
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Cytoplasmic Dyneins / metabolism*
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Microtubules / metabolism
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Models, Biological
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Molecular Motor Proteins / chemistry
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Molecular Motor Proteins / metabolism
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Protein Binding
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Protein Isoforms / chemistry
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Protein Isoforms / genetics
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Protein Isoforms / metabolism*
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Protein Subunits / chemistry
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Protein Subunits / genetics
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Protein Subunits / metabolism
Substances
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Molecular Motor Proteins
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Protein Isoforms
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Protein Subunits
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Cytoplasmic Dyneins