KRAS-induced actin-interacting protein: a potent target for obesity, diabetes and cancer

Takahiro Fujimoto; Senji Shirasawa

KRAS-induced actin-interacting protein: a potent target for obesity, diabetes and cancer

Anticancer Res. 2011 Jul;31(7):2413-7.

Authors

Takahiro Fujimoto¹, Senji Shirasawa

Affiliation

¹ Department of Cell Biology, Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan.

PMID: 21873152

Abstract

KRAS-induced actin-interacting protein (KRAP) was originally identified as one of the genes deregulated in colorectal cancer. KRAP encodes a cytoplasmic protein associated with filamentous-actin (F-actin), and the amino acid sequences are highly conserved among KRAP orthologues from fish to mammalian species. We demonstrated that KRAP-deficient mice show altered whole-body energy metabolism and resistance to diet-induced obesity and diabetes. Although the precise mechanisms underlying the metabolic phenotypes in the KRAP-deficient mice remain unclear, KRAP is considered to be a target for metabolism-related diseases. Furthermore, several groups have reported that KRAP is a cancer-associated gene. Further studies on the molecular functions of KRAP in physiological tissues could provide a better understanding of various diseases, and opportunities for intervention in various human diseases. In this review, we summarize the current understanding of KRAP and the roles that it plays in a variety of diseases.

Publication types

Review

MeSH terms

Adipose Tissue / metabolism
Animals
Cell Line, Tumor
Colorectal Neoplasms / pathology
Diabetes Mellitus / drug therapy*
Energy Metabolism / genetics
Energy Metabolism / physiology*
Humans
Membrane Proteins / antagonists & inhibitors
Membrane Proteins / chemistry
Membrane Proteins / genetics
Membrane Proteins / physiology*
Mice
Microfilament Proteins / antagonists & inhibitors
Microfilament Proteins / chemistry
Microfilament Proteins / deficiency
Microfilament Proteins / genetics
Microfilament Proteins / physiology*
Molecular Targeted Therapy*
Neoplasms / drug therapy*
Obesity / drug therapy*
Obesity / prevention & control
Organ Specificity
Phenotype
Phylogeny
Proto-Oncogene Proteins / physiology
Proto-Oncogene Proteins p21(ras)
Signal Transduction / drug effects
Signal Transduction / physiology
Thinness / genetics
ras Proteins / physiology

Substances

ITPRID2 protein, human
KRAP protein, mouse
KRAS protein, human
Membrane Proteins
Microfilament Proteins
Proto-Oncogene Proteins
Proto-Oncogene Proteins p21(ras)
ras Proteins