Common variation at 10p12.31 near MLLT10 influences meningioma risk

Nat Genet. 2011 Jul 31;43(9):825-7. doi: 10.1038/ng.879.

Abstract

To identify susceptibility loci for meningioma, we conducted a genome-wide association study of 859 affected individuals (cases) and 704 controls with validation in two independent sample sets totaling 774 cases and 1,764 controls. We identified a new susceptibility locus for meningioma at 10p12.31 (MLLT10, rs11012732, odds ratio = 1.46, P(combined) = 1.88 × 10(-14)). This finding advances our understanding of the genetic basis of meningioma development.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Chromosomes, Human, Pair 10 / genetics*
  • Genetic Loci
  • Genetic Predisposition to Disease*
  • Genome-Wide Association Study
  • Humans
  • Male
  • Meningeal Neoplasms / epidemiology
  • Meningeal Neoplasms / genetics*
  • Meningioma / epidemiology
  • Meningioma / genetics*
  • Polymorphism, Genetic
  • Polymorphism, Single Nucleotide
  • Risk
  • Transcription Factors / genetics*

Substances

  • MLLT10 protein, human
  • Transcription Factors