HLA rs3129882 variant in Chinese Han patients with late-onset sporadic Parkinson disease

Neurosci Lett. 2011 Sep 1;501(3):185-7. doi: 10.1016/j.neulet.2011.05.245. Epub 2011 Jul 20.

Abstract

Recently, the rs3129882 variant in intron 1 of HLA-DRA was found to be associated with late-onset sporadic Parkinson disease (PD) in Americans of European ancestry. To evaluate whether the same variant is related to PD in Chinese population, we investigated late-onset sporadic PD patients of Chinese Han ethanicity in Mainland China. We found significant difference in genotypic and allele distribution between patients and control subjects (χ²)=6.446, p=0.040 for genotypic distribution; χ²=5.762, p=0.016 for allele distribution), suggesting this variant is associated with late-onset sporadic PD in Chinese Han population.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Age of Onset
  • Aged
  • Asian People / ethnology*
  • Asian People / genetics*
  • China / epidemiology
  • Female
  • Gene Frequency / genetics
  • Genetic Predisposition to Disease / ethnology
  • Genetic Predisposition to Disease / genetics*
  • Genetic Variation / genetics*
  • Genotype
  • HLA-DR alpha-Chains / genetics*
  • Humans
  • Introns / genetics
  • Male
  • Middle Aged
  • Parkinson Disease / blood*
  • Parkinson Disease / ethnology
  • Parkinson Disease / genetics*
  • Polymorphism, Genetic / genetics

Substances

  • HLA-DR alpha-Chains