Inflammation: cell recruitment versus local proliferation

Curr Biol. 2011 Jul 26;21(14):R548-50. doi: 10.1016/j.cub.2011.06.005.

Abstract

Inflammation leads to local accumulation of macrophages. A new study shows that macrophage accumulation in inflammatory reactions dominated by type 2 immune responses is a result of local cell proliferation as opposed to recruitment of monocytes from the blood.

MeSH terms

  • Animals
  • Antineoplastic Combined Chemotherapy Protocols
  • Blood
  • Cell Proliferation
  • Cisplatin
  • Filariasis / immunology
  • Filarioidea / immunology
  • Ifosfamide
  • Inflammation / immunology*
  • Interleukin-4 / immunology
  • Macrophage Activation
  • Macrophages / cytology
  • Macrophages / immunology*
  • Mitomycin
  • Monocytes / cytology
  • Monocytes / immunology
  • Th2 Cells / immunology*

Substances

  • Interleukin-4
  • Mitomycin
  • Cisplatin
  • Ifosfamide

Supplementary concepts

  • MIP protocol