Abstract
In this study, we investigated the effect of fish oil on gene expression in the cerebral cortex, and found that 5-aminolevulinate synthase 2 (ALAS2) mRNA expression was up-regulated by fish oil feeding. ALAS2 promoter activity was found to be regulated by retinoic acid. Our results suggest that fish oil modulates neuronal functions via heme synthesis.
MeSH terms
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5-Aminolevulinate Synthetase / biosynthesis
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5-Aminolevulinate Synthetase / genetics*
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5-Aminolevulinate Synthetase / metabolism*
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Animals
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Cerebral Cortex / metabolism*
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Docosahexaenoic Acids / administration & dosage
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Docosahexaenoic Acids / metabolism
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Fish Oils / administration & dosage*
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Fish Oils / metabolism
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Gene Expression
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Heme / biosynthesis
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RNA, Messenger / biosynthesis
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RNA, Messenger / genetics
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RNA, Messenger / metabolism*
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Rats
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Tretinoin / chemistry
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Tretinoin / metabolism*
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Up-Regulation
Substances
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Fish Oils
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RNA, Messenger
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Docosahexaenoic Acids
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Heme
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Tretinoin
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5-Aminolevulinate Synthetase