Effect of cholesterol and CYP46 polymorphism on cognitive event-related potentials

Psychophysiology. 2011 Nov;48(11):1572-1577. doi: 10.1111/j.1469-8986.2011.01221.x. Epub 2011 Jul 5.

Abstract

The integrated effect of the cholesterol and CYP46 genotypes on the risk of cognitive decline needs to be determined. Using the Cognitive Abilities Screening Instrument (CASI), 145 mentally healthy middle-aged and older adults were recruited to investigate the influence of cholesterol and CYP46 genotypes on cognitive event-related potentials (ERPs). The subjects with a high low-density lipoprotein cholesterol (LDL-C) level displayed significantly lower amplitude ERPs, although the CASI scores showed no difference. There was no association between the CYP46 genotypes, CASI scores, cholesterol levels, and measures of ERPs. No interaction between LDL-C level and CYP46 genotypes was noted. The LDL-C level is an independent predictor of low P300 amplitude. Prevention and treatment of high cholesterol may be of potential benefit in reducing cognitive impairment.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Cholesterol / blood*
  • Cholesterol 24-Hydroxylase
  • Cognition / physiology*
  • Evoked Potentials / genetics
  • Evoked Potentials / physiology*
  • Female
  • Genotype
  • Humans
  • Male
  • Middle Aged
  • Polymorphism, Single Nucleotide*
  • Steroid Hydroxylases / genetics*

Substances

  • Cholesterol
  • Steroid Hydroxylases
  • Cholesterol 24-Hydroxylase