Abstract
Livin is a member of the inhibitors of apoptosis (IAP) family, which plays crucial roles in apoptosis, cell proliferation, and cell cycle control. Abnormal Livin expression is sometimes detected during the process of cancer formation and/or progression. Thus, Livin research may provide an opportunity for the development of potential therapy for Livin-relevant cancers. In this review, we introduce Livin structure, biological function, and its role in cancer formation and progression and the possible interventions for cancer therapy.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Adaptor Proteins, Signal Transducing / chemistry
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Adaptor Proteins, Signal Transducing / genetics
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Adaptor Proteins, Signal Transducing / metabolism*
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Apoptosis / genetics*
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Cell Cycle Checkpoints / genetics
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Cell Line, Tumor
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Cell Proliferation
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Disease Progression
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Gene Expression Regulation, Neoplastic
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Humans
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Inhibitor of Apoptosis Proteins / chemistry
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Inhibitor of Apoptosis Proteins / genetics
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Inhibitor of Apoptosis Proteins / metabolism*
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Neoplasm Proteins / chemistry
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Neoplasm Proteins / genetics
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Neoplasm Proteins / metabolism*
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Neoplasms / genetics
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Neoplasms / metabolism*
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Neoplasms / therapy
Substances
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Adaptor Proteins, Signal Transducing
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BIRC7 protein, human
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Inhibitor of Apoptosis Proteins
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Neoplasm Proteins