Homology of cytokine synthesis inhibitory factor (IL-10) to the Epstein-Barr virus gene BCRFI

K W Moore; P Vieira; D F Fiorentino; M L Trounstine; T A Khan; T R Mosmann

doi:10.1126/science.2161559

Homology of cytokine synthesis inhibitory factor (IL-10) to the Epstein-Barr virus gene BCRFI

Science. 1990 Jun 8;248(4960):1230-4. doi: 10.1126/science.2161559.

Authors

K W Moore¹, P Vieira, D F Fiorentino, M L Trounstine, T A Khan, T R Mosmann

Affiliation

¹ Department of Immunology, DNAX Research Institute, Palo Alto, CA 94304.

PMID: 2161559
DOI: 10.1126/science.2161559

Abstract

Complementary DNA clones encoding mouse cytokine synthesis inhibitory factor (CSIF; interleukin-10), which inhibits cytokine synthesis by TH1 helper T cells, were isolated and expressed. The predicted protein sequence shows extensive homology with an uncharacterized open reading frame, BCRFI, in the Epstein-Barr virus genome, suggesting the possibility that this herpes virus exploits the biological activity of a captured cytokine gene to enhance its survival in the host.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Amino Acid Sequence
Animals
Base Sequence
Cell Line
Cloning, Molecular
Codon / genetics
Genes, Viral*
Herpesvirus 4, Human / genetics*
Interleukin-10
Interleukins / genetics*
Mice
Molecular Sequence Data
Nucleic Acid Hybridization
RNA, Messenger / genetics
Restriction Mapping
Sequence Homology, Nucleic Acid
T-Lymphocytes, Helper-Inducer / immunology
Transfection

Substances

Codon
Interleukins
RNA, Messenger
Interleukin-10

Associated data

GENBANK/M37897