Single nucleotide polymorphism in the UBR2 gene may be a genetic risk factor for Japanese patients with azoospermia by meiotic arrest

J Assist Reprod Genet. 2011 Aug;28(8):743-6. doi: 10.1007/s10815-011-9576-y. Epub 2011 May 4.

Abstract

Purpose: To investigate the association between the UBR2 gene and the risk of azoospermia caused by meiotic arrest.

Methods: Mutational analysis of the UBR2 gene was performed using DNA from 30 patients with azoospermia by meiotic arrest to 80 normal controls.

Results: The genotypic and allelic frequencies of c.1,066A>T variant were significantly higher in patient than control groups (p < 0.001).

Conclusion: The c.1,066A>T variant in the UBR2 gene is associated with increased susceptibility to azoospermia caused by meiotic arrest.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Asian People*
  • Azoospermia / ethnology
  • Azoospermia / genetics*
  • Case-Control Studies
  • DNA Mutational Analysis
  • Gene Frequency
  • Genetic Association Studies
  • Genotype
  • Humans
  • Male
  • Meiosis*
  • Polymorphism, Single Nucleotide*
  • Risk Factors
  • Ubiquitin-Protein Ligases / genetics*

Substances

  • UBR2 protein, human
  • Ubiquitin-Protein Ligases