Genetics of atopic dermatitis

Caroline Bussmann; Stephan Weidinger; Natalija Novak

doi:10.1111/j.1610-0387.2011.07656.x

Genetics of atopic dermatitis

J Dtsch Dermatol Ges. 2011 Sep;9(9):670-6. doi: 10.1111/j.1610-0387.2011.07656.x. Epub 2011 Apr 26.

[Article in English, German]

Authors

Caroline Bussmann¹, Stephan Weidinger, Natalija Novak

Affiliation

¹ Department of Dermatology and Allergy, University of Bonn, Germany.

PMID: 21518425
DOI: 10.1111/j.1610-0387.2011.07656.x

Abstract

Atopic dermatitis (AD) is a multifactorial disease, with a strong genetic predisposition. Genome-wide studies as well as candidate gene studies revealed several susceptibility loci. Since the observation of a strong association of "loss of function" mutations in the filaggrin gene with AD, the epidermal barrier was rediscovered as important pathophysiological co-factor of this disease.

Publication types

Review

MeSH terms

Adaptive Immunity / genetics
Alleles
DNA Mutational Analysis
Dermatitis, Atopic / diagnosis
Dermatitis, Atopic / genetics*
Diseases in Twins / genetics
Filaggrin Proteins
Gene Frequency / genetics
Genetic Association Studies
Genetic Predisposition to Disease / genetics*
Genome-Wide Association Study
Humans
Immunity, Innate / genetics
Immunoglobulin E / blood
Intermediate Filament Proteins / genetics*
Polymorphism, Single Nucleotide / genetics
Risk Factors
Skin / immunology

Substances

FLG protein, human
Filaggrin Proteins
Intermediate Filament Proteins
Immunoglobulin E