Abstract
Exaggerated recall for fear-provoking events leads to abnormal behaviors. We hypothesized that tuberoinfundibular-peptide-of-39-residues (TIP39) modulates fear memory by limiting long-term consequences of aversive experiences. We now show that mice lacking TIP39 signaling display enhanced fear-recall, anxiety and depression-like behavior 2 weeks after a traumatic event. We suggest that TIP39 modulates long-term fear recall and that mice lacking TIP39 or its receptor are tools for investigating fear-related psychopathologies.
Published by Elsevier B.V.
Publication types
-
Research Support, N.I.H., Intramural
MeSH terms
-
Animals
-
Anxiety / genetics
-
Anxiety / physiopathology*
-
Avoidance Learning / physiology
-
Depression / genetics
-
Depression / physiopathology*
-
Disease Models, Animal
-
Exploratory Behavior
-
Fear / physiology*
-
Maze Learning
-
Memory, Long-Term / physiology*
-
Mice
-
Mice, Inbred C57BL
-
Mice, Knockout
-
Nuclear Proteins / deficiency*
-
RNA Splicing Factors
-
RNA-Binding Proteins
-
Receptor, Parathyroid Hormone, Type 2 / deficiency
-
Signal Transduction / genetics
-
Signal Transduction / physiology*
-
Time Factors
-
Vesicular Transport Proteins / deficiency*
Substances
-
Nuclear Proteins
-
RNA Splicing Factors
-
RNA-Binding Proteins
-
Receptor, Parathyroid Hormone, Type 2
-
Tfip11 protein, mouse
-
Vesicular Transport Proteins