Abstract
Connexins (Cx) are transmembrane proteins forming vertebrate gap junction channels for direct cell-cell communication. We found that the expressions of two Cx family members, Cx29 and Cx32, were progressively increased in the sharp border of injury penumbra regions after cryotraumatic brain injury. Although these two Cxs are expressed exclusively in the oligodendrocytes in the normal cerebral cortex, their expressions were increased in the astrocytes and microglia localized in the injury border. Highly selective induction of Cxs in the injury border suggests that altered Cxs may contribute to the propagations of injury-related and/or regeneration signals after acute brain injury.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acute Disease
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Animals
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Astrocytes / metabolism
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Astrocytes / pathology
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Brain Injuries / etiology
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Brain Injuries / metabolism*
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Brain Injuries / pathology*
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Connexins / biosynthesis*
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Connexins / genetics
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Disease Models, Animal
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Gap Junction beta-1 Protein
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Male
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Membrane Proteins / biosynthesis*
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Membrane Proteins / genetics
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Mice
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Mice, Inbred C57BL
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Microglia / metabolism
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Microglia / pathology
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Nerve Regeneration / genetics
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Nerve Tissue Proteins / biosynthesis*
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Nerve Tissue Proteins / genetics
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Oligodendroglia / metabolism
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Oligodendroglia / pathology
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Reaction Time / genetics
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Signal Transduction / genetics
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Tetraspanins
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Up-Regulation / genetics
Substances
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Connexins
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Gje1 protein, mouse
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Membrane Proteins
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Nerve Tissue Proteins
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TSPAN33 protein, human
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Tetraspanins