Apoptosis: embedded in membranes

Curr Opin Cell Biol. 2010 Dec;22(6):845-51. doi: 10.1016/j.ceb.2010.08.002. Epub 2010 Aug 26.

Abstract

Many different signals for cell death converge on outer mitochondrial membrane permeabilization, a process controlled by the Bcl-2 family of proteins. Recent structural and biochemical analyses emphasize that key regulatory interactions between different classes of Bcl-2 family members occur at and in intracellular membranes, and insertion into membranes causes functionally important conformational changes in the proteins.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Apoptosis / physiology*
  • Mitochondrial Membranes / metabolism*
  • Protein Structure, Quaternary
  • Proto-Oncogene Proteins c-bcl-2 / chemistry
  • Proto-Oncogene Proteins c-bcl-2 / genetics
  • Proto-Oncogene Proteins c-bcl-2 / metabolism
  • bcl-2-Associated X Protein / chemistry
  • bcl-2-Associated X Protein / genetics
  • bcl-2-Associated X Protein / metabolism
  • bcl-X Protein / chemistry
  • bcl-X Protein / genetics
  • bcl-X Protein / metabolism

Substances

  • Proto-Oncogene Proteins c-bcl-2
  • bcl-2-Associated X Protein
  • bcl-X Protein