The genome sequence of the cyanobacterium Oscillatoria sp. PCC 6506 reveals several gene clusters responsible for the biosynthesis of toxins and secondary metabolites

Annick Méjean; Rabia Mazmouz; Stéphane Mann; Alexandra Calteau; Claudine Médigue; Olivier Ploux

doi:10.1128/JB.00704-10

The genome sequence of the cyanobacterium Oscillatoria sp. PCC 6506 reveals several gene clusters responsible for the biosynthesis of toxins and secondary metabolites

J Bacteriol. 2010 Oct;192(19):5264-5. doi: 10.1128/JB.00704-10. Epub 2010 Jul 30.

Authors

Annick Méjean¹, Rabia Mazmouz, Stéphane Mann, Alexandra Calteau, Claudine Médigue, Olivier Ploux

Affiliation

¹ Laboratoire Charles Friedel, UMR CNRS 7223, ENSCP Chimie ParisTech, 11 Rue Pierre et Marie Curie, 75231 Paris Cedex 05, France. annick-mejean@enscp.fr

Abstract

We report a draft sequence of the genome of Oscillatoria sp. PCC 6506, a cyanobacterium that produces anatoxin-a and homoanatoxin-a, two neurotoxins, and cylindrospermopsin, a cytotoxin. Beside the clusters of genes responsible for the biosynthesis of these toxins, we have found other clusters of genes likely involved in the biosynthesis of not-yet-identified secondary metabolites.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Bacterial Toxins / genetics
Genome, Bacterial / genetics*
Molecular Sequence Data
Multigene Family / genetics*
Multigene Family / physiology
Oscillatoria / genetics*

Substances

Bacterial Toxins

Associated data

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