Genetic loci influencing kidney function and chronic kidney disease

Nat Genet. 2010 May;42(5):373-5. doi: 10.1038/ng.566. Epub 2010 Apr 11.

Abstract

Using genome-wide association, we identify common variants at 2p12-p13, 6q26, 17q23 and 19q13 associated with serum creatinine, a marker of kidney function (P = 10(-10) to 10(-15)). Of these, rs10206899 (near NAT8, 2p12-p13) and rs4805834 (near SLC7A9, 19q13) were also associated with chronic kidney disease (P = 5.0 x 10(-5) and P = 3.6 x 10(-4), respectively). Our findings provide insight into metabolic, solute and drug-transport pathways underlying susceptibility to chronic kidney disease.

MeSH terms

  • Biological Transport
  • Creatinine / blood
  • Cystatin C / metabolism
  • Europe
  • Gene Expression Regulation
  • Genetic Markers / genetics
  • Genetic Predisposition to Disease
  • Genetic Variation
  • Genome-Wide Association Study
  • Genotype
  • Glomerular Filtration Rate
  • Humans
  • Kidney / physiology*
  • Kidney Failure, Chronic / genetics*
  • Kidney Failure, Chronic / pathology
  • Models, Genetic

Substances

  • Cystatin C
  • Genetic Markers
  • Creatinine