Polymorphisms of chitinases are not associated with asthma

J Allergy Clin Immunol. 2010 Mar;125(3):754-7, 757.e1-757.e2. doi: 10.1016/j.jaci.2009.12.995.

Abstract

Despite the potential role of chitinases and chitinase-like proteins in the pathogenesis of asthma, variants in their respective genes are not associated with asthma, changes in lung physiology or allergy-related phenotypes in Caucasian children.

Publication types

  • Letter
  • Research Support, N.I.H., Extramural

MeSH terms

  • Adipokines
  • Adolescent
  • Anti-Asthmatic Agents / therapeutic use
  • Asthma / drug therapy
  • Asthma / genetics*
  • Budesonide / therapeutic use
  • Child
  • Child, Preschool
  • Chitin Synthase / genetics*
  • Chitinase-3-Like Protein 1
  • Chitinases / genetics*
  • Female
  • Genetic Predisposition to Disease*
  • Genotype
  • Glycoproteins / genetics*
  • Humans
  • Lectins / genetics*
  • Male
  • Multicenter Studies as Topic
  • Nedocromil / therapeutic use
  • Polymerase Chain Reaction
  • Polymorphism, Single Nucleotide
  • Randomized Controlled Trials as Topic

Substances

  • Adipokines
  • Anti-Asthmatic Agents
  • CHI3L1 protein, human
  • Chitinase-3-Like Protein 1
  • Glycoproteins
  • Lectins
  • Nedocromil
  • Budesonide
  • Chitin Synthase
  • CHIA protein, human
  • Chitinases