Recent excitement in the DNA replication problem

Nature. 1977 Oct 20;269(5630):655-61. doi: 10.1038/269655a0.

Abstract

It is now possible to reproduce most of the reactions involved in DNA replication using prokaryotic enzymes in vitro. Such systems have revealed that DNA replication is a complex process depending on a relatively large number of proteins, and that nucleoside triphosphate hydrolysis energy is used at several discrete steps. Much of the complexity of DNA replication may arise from the need for extreme copying fidelity.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Adenosine Triphosphate / metabolism
  • Coliphages / genetics
  • DNA Helicases / metabolism
  • DNA Replication*
  • DNA, Bacterial / genetics
  • DNA, Viral / genetics
  • DNA-Directed DNA Polymerase / metabolism
  • Escherichia coli / genetics
  • Mutation
  • Nucleic Acid Conformation

Substances

  • DNA, Bacterial
  • DNA, Viral
  • Adenosine Triphosphate
  • DNA-Directed DNA Polymerase
  • DNA Helicases