Crystal structure of HIV-1 reverse transcriptase bound to a non-nucleoside inhibitor with a novel mechanism of action

Angew Chem Int Ed Engl. 2010 Mar 1;49(10):1805-8. doi: 10.1002/anie.200905651.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-HIV Agents / chemistry*
  • Anti-HIV Agents / therapeutic use
  • Crystallography, X-Ray
  • HIV Protease Inhibitors / chemistry*
  • HIV Protease Inhibitors / metabolism
  • HIV Protease Inhibitors / pharmacology
  • HIV Reverse Transcriptase / chemistry*
  • HIV Reverse Transcriptase / metabolism
  • Heterocyclic Compounds, 3-Ring / chemistry*
  • Humans
  • Indoles / chemistry*
  • Models, Biological*
  • Models, Molecular*
  • Molecular Structure
  • Nitriles / chemistry*
  • Pyridones / chemistry*
  • Pyrimidines / chemistry*
  • Reverse Transcriptase Inhibitors / chemistry*
  • Reverse Transcriptase Inhibitors / therapeutic use
  • Vinyl Compounds / chemistry*

Substances

  • 4-dimethylamino-6-vinylpyrimidine
  • 5-methyl-1-(4-nitrophenyl)-2-oxo-2,5-dihydro-1H-pyrido(3,2-b)indole-3-carbonitrile
  • Anti-HIV Agents
  • HIV Protease Inhibitors
  • Heterocyclic Compounds, 3-Ring
  • Indoles
  • Nitriles
  • Pyridones
  • Pyrimidines
  • Reverse Transcriptase Inhibitors
  • VRX-329747
  • VRX-413638
  • Vinyl Compounds
  • reverse transcriptase, Human immunodeficiency virus 1
  • HIV Reverse Transcriptase