Abstract
To date, understanding of the molecular mechanisms of bone metabolism has centered on three tumor necrosis factor family members--RANK, its ligand RANKL and its decoy receptor osteoprotegrin. This view should now be modified, however, to incorporate the role of interferon regulatory factor-8.
MeSH terms
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Animals
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Interferon Regulatory Factors / metabolism*
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Osteoclasts / physiology*
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Osteoporosis / metabolism*
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Osteoprotegerin / metabolism
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RANK Ligand / metabolism
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Receptor Activator of Nuclear Factor-kappa B / metabolism
Substances
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Interferon Regulatory Factors
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Osteoprotegerin
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RANK Ligand
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Receptor Activator of Nuclear Factor-kappa B
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interferon regulatory factor-8