Bone diseases: Interferon regulatory factor-8 suppresses osteoclastogenesis

Nat Rev Rheumatol. 2010 Feb;6(2):73-4. doi: 10.1038/nrrheum.2009.274.

Abstract

To date, understanding of the molecular mechanisms of bone metabolism has centered on three tumor necrosis factor family members--RANK, its ligand RANKL and its decoy receptor osteoprotegrin. This view should now be modified, however, to incorporate the role of interferon regulatory factor-8.

Publication types

  • News

MeSH terms

  • Animals
  • Interferon Regulatory Factors / metabolism*
  • Osteoclasts / physiology*
  • Osteoporosis / metabolism*
  • Osteoprotegerin / metabolism
  • RANK Ligand / metabolism
  • Receptor Activator of Nuclear Factor-kappa B / metabolism

Substances

  • Interferon Regulatory Factors
  • Osteoprotegerin
  • RANK Ligand
  • Receptor Activator of Nuclear Factor-kappa B
  • interferon regulatory factor-8