Genome sequence of a recently emerged, highly transmissible, multi-antibiotic- and antiseptic-resistant variant of methicillin-resistant Staphylococcus aureus, sequence type 239 (TW)

J Bacteriol. 2010 Feb;192(3):888-92. doi: 10.1128/JB.01255-09. Epub 2009 Nov 30.

Abstract

The 3.1-Mb genome of an outbreak methicillin-resistant Staphylococcus aureus (MRSA) strain (TW20) contains evidence of recently acquired DNA, including two large regions (635 kb and 127 kb). The strain is resistant to a wide range of antibiotics, antiseptics, and heavy metals due to resistance genes encoded on mobile genetic elements and also mutations in housekeeping genes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / pharmacology
  • Anti-Infective Agents, Local / pharmacology
  • Drug Resistance, Multiple, Bacterial / genetics*
  • Genome, Bacterial / genetics*
  • Metals, Heavy / toxicity
  • Methicillin-Resistant Staphylococcus aureus / drug effects
  • Methicillin-Resistant Staphylococcus aureus / genetics*
  • Models, Genetic
  • Molecular Sequence Data

Substances

  • Anti-Bacterial Agents
  • Anti-Infective Agents, Local
  • Metals, Heavy

Associated data

  • GENBANK/FN433596
  • GENBANK/FN433597
  • GENBANK/FN433598