Genetic analysis of the NEUROG2 gene in patients with Parkinson's disease

Neurosci Lett. 2010 Jan 14;468(3):195-7. doi: 10.1016/j.neulet.2009.10.078. Epub 2009 Oct 29.

Abstract

The proneural protein Neurogenin 2 (NEUROG2) is a transcription factor of importance for the differentiation and survival of midbrain dopaminergic neurons. To determine whether genetic variation in the coding region of the NEUROG2 gene plays a role in the etiology of Parkinson's disease (PD), we screened DNA samples from 202 PD patients and 201 normal controls. No mutation in the NEUROG2 gene was identified in our PD cohort, except that novel compound heterozygous variants (Gly56Arg and Asp206Glu) were found in a 91-year normal male, suggesting that mutations in the coding region of the NEUROG2 gene play little or no role in the development of PD.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Basic Helix-Loop-Helix Transcription Factors / genetics*
  • Genetic Association Studies
  • Humans
  • Male
  • Middle Aged
  • Mutation
  • Nerve Tissue Proteins / genetics*
  • Parkinson Disease / genetics*

Substances

  • Basic Helix-Loop-Helix Transcription Factors
  • NEUROG2 protein, human
  • Nerve Tissue Proteins