Rif proteins take to the RhoD: Rho GTPases at the crossroads of actin dynamics and membrane trafficking

Annica K B Gad; Pontus Aspenström

doi:10.1016/j.cellsig.2009.10.001

Rif proteins take to the RhoD: Rho GTPases at the crossroads of actin dynamics and membrane trafficking

Cell Signal. 2010 Feb;22(2):183-9. doi: 10.1016/j.cellsig.2009.10.001. Epub 2009 Oct 7.

Authors

Annica K B Gad¹, Pontus Aspenström

Affiliation

¹ Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden.

PMID: 19818399
DOI: 10.1016/j.cellsig.2009.10.001

Abstract

The Rif and RhoD proteins belong to the Rho subfamily of small GTPases. Rif and RhoD have for too long remained in the shadows of the better known Rho GTPases Cdc42, Rac1 and RhoA. With this review article, our aim is to provide the currently available information regarding Rif and RhoD. Taken together, the data available to date indicate that Rif and RhoD have unique roles in the regulation of actin dynamics, and that RhoD can link actin reorganisation to endosomal vesicle transport.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Actins / chemistry
Actins / metabolism*
Amino Acid Sequence
Humans
Molecular Sequence Data
Sequence Alignment
Substrate Specificity
rho GTP-Binding Proteins / metabolism*
rho GTP-Binding Proteins / physiology

Substances

Actins
RHOD protein, human
RHOF protein, human
rho GTP-Binding Proteins