Variations of specific non-candidate genes and risk of myocardial infarction: a replication study

Background: A recent survey of 11,053 single nucleotide polymorphisms from 6891 genes suggested that the risk of myocardial infarction was related to specific genes so far not linked with atherosclerotic diseases. The genes encode the cytoskeletal protein palladin (PALLD), a receptor tyrosine kinase (ROS1), a taste receptor (TAS2R50), an olfactory receptor (OR13G1), and a zinc finger protein (ZNF627).

Methods: We examined the polymorphisms rs12510359 (PALLD), rs619203 (ROS1), rs1376251 (TAS2R50), rs1151640 (OR13G1), and rs4804611 (ZNF627) which were found to be associated with myocardial infarction in the original report. The present study sample consisted of 3657 patients with myocardial infarction (885 women and 2772 men) and 1211 control individuals (598 women and 613 men).

Results: The frequencies of genotypes and alleles were not significantly different between the group with myocardial infarction and the control group (p ≥ 0.25). In addition, genotype distributions were not substantially different between the women in the group with myocardial infarction and the control group (p ≥ 0.30) and between the men in the two groups (p ≥ 0.27). Finally, no risk genotypes were ascertained in multiple logistic regression analyses that included conventional risk factors of atherosclerosis as covariates (p≥0.26).

Conclusions: The results obtained in this study argue against associations of specific single nucleotide polymorphisms in the PALLD, ROS1, TAS2R50, OR13G1, and ZNF627 genes with myocardial infarction.