The human cardiac troponin I locus: assignment to chromosome 19p13.2-19q13.2

C MacGeoch; P J Barton; W J Vallins; P Bhavsar; N K Spurr

doi:10.1007/BF00204938

The human cardiac troponin I locus: assignment to chromosome 19p13.2-19q13.2

Hum Genet. 1991 Nov;88(1):101-4. doi: 10.1007/BF00204938.

Authors

C MacGeoch¹, P J Barton, W J Vallins, P Bhavsar, N K Spurr

Affiliation

¹ Imperial Cancer Research Fund, Clare Hall Laboratories, Potters Bar, Herts, UK.

PMID: 1959915
DOI: 10.1007/BF00204938

Abstract

The three major troponin I isoforms are encoded by separate genes and are expressed in a muscle-type-specific manner. A human cardiac troponin I cDNA has recently been isolated and used to establish the genomic location of the cardiac troponin I gene locus (designated TNNC1). By somatic cell hybrid analysis, the locus for TNNC1 maps to human chromosome 19 and can be localised to the region p13.2-q13.2.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cell Line
Chromosome Mapping
Chromosomes, Human, Pair 19*
Humans
Myocardium*
Troponin / genetics*
Troponin I

Substances

Troponin
Troponin I