Abstract
Finding the right fit: Herein, we report on the development of novel steric probes and present initial insights into their interplay with DNA polymerases. Our findings provide experimental evidence for varied enzyme-substrate interactions that might account for the varied selectivity previously observed.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Base Pairing
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Catalytic Domain*
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DNA Polymerase I / chemistry*
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DNA Polymerase I / metabolism
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DNA Polymerase beta / chemistry*
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DNA Polymerase beta / metabolism
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Kinetics
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Nucleotides / chemistry*
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Substrate Specificity
Substances
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Nucleotides
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DNA Polymerase I
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DNA Polymerase beta