Synthesis and DNA polymerase alpha and beta inhibitory activity of alkyl p-coumarates and related compounds

Katsumi Nishimura; Yukiko Takenaka; Manami Kishi; Takao Tanahashi; Hiromi Yoshida; Chiaki Okuda; Yoshiyuki Mizushina

doi:10.1248/cpb.57.476

Synthesis and DNA polymerase alpha and beta inhibitory activity of alkyl p-coumarates and related compounds

Chem Pharm Bull (Tokyo). 2009 May;57(5):476-80. doi: 10.1248/cpb.57.476.

Authors

Katsumi Nishimura¹, Yukiko Takenaka, Manami Kishi, Takao Tanahashi, Hiromi Yoshida, Chiaki Okuda, Yoshiyuki Mizushina

Affiliation

¹ Kobe Pharmaceutical University, Kobe, Japan. nishi@kobepharma-u.ac.jp

PMID: 19420778
DOI: 10.1248/cpb.57.476

Abstract

trans- and cis-Icosyl, docosyl, and tetracosyl p-coumarates, constituents of Artemisia annua L., and their structurally-related compounds were synthesized and evaluated for inhibitory activity on DNA polymerases alpha and beta. Among 30 compounds synthesized, octadecyl trans- and cis-p-coumarates and octadecyl p-hydroxyphenylpropiolate showed strong inhibitory activity on DNA polymerases alpha and beta.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Coumaric Acids / chemical synthesis*
Coumaric Acids / chemistry
Coumaric Acids / pharmacology*
DNA Polymerase I / antagonists & inhibitors
DNA Polymerase I / chemistry*
DNA Polymerase beta / antagonists & inhibitors
DNA Polymerase beta / chemistry*
Enzyme Inhibitors / pharmacology*
Esters / chemical synthesis
Esters / chemistry*
Esters / pharmacology
Humans
Inhibitory Concentration 50
Molecular Structure

Substances

Coumaric Acids
Enzyme Inhibitors
Esters
DNA Polymerase I
DNA Polymerase beta