Hematopoietic stem and progenitor cells: their mobilization and homing to bone marrow and peripheral tissue

Immunol Res. 2009;44(1-3):160-8. doi: 10.1007/s12026-009-8109-6.

Abstract

Hematopoietic stem and progenitor cells (HSPCs) are a rare population of precursor cells that possess the capacity for self-renewal and multilineage differentiation. In the bone marrow (BM), HSPCs warrant blood cell homeostasis. In addition, they may also replenish tissue-resident myeloid cells and directly participate in innate immune responses once they home to peripheral tissues. In this review, we summarize recent data on the signaling molecules that modulate the mobilization of HSPCs from BM and their migration to peripheral tissues.

Publication types

  • Review

MeSH terms

  • Animals
  • Bone Marrow / immunology*
  • Cell Movement*
  • Chemokine CXCL12 / immunology
  • Chemokine CXCL12 / metabolism
  • Hematopoietic Stem Cells / immunology*
  • Humans
  • Intercellular Signaling Peptides and Proteins / immunology
  • Intercellular Signaling Peptides and Proteins / metabolism
  • Lysophospholipids / immunology
  • Lysophospholipids / metabolism
  • Nitric Oxide / immunology
  • Nitric Oxide / metabolism
  • Receptor, Parathyroid Hormone, Type 1 / immunology
  • Receptor, Parathyroid Hormone, Type 1 / metabolism
  • Receptors, CCR2 / immunology
  • Receptors, CCR2 / metabolism
  • Sphingosine / analogs & derivatives
  • Sphingosine / immunology
  • Sphingosine / metabolism
  • Toll-Like Receptors / immunology
  • Toll-Like Receptors / metabolism
  • Transforming Growth Factor beta / immunology
  • Transforming Growth Factor beta / metabolism

Substances

  • Chemokine CXCL12
  • Intercellular Signaling Peptides and Proteins
  • Lysophospholipids
  • Receptor, Parathyroid Hormone, Type 1
  • Receptors, CCR2
  • Toll-Like Receptors
  • Transforming Growth Factor beta
  • sphingosine 1-phosphate
  • Nitric Oxide
  • Sphingosine