Structure of the thioredoxin-fold domain of human phosducin-like protein 2

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Feb 1;65(Pt 2):67-70. doi: 10.1107/S1744309108037342. Epub 2009 Jan 31.

Abstract

Human phosducin-like protein 2 (hPDCL2) has been identified as belonging to subgroup II of the phosducin (Pdc) family. The members of this family share an N-terminal helix domain and a C-terminal thioredoxin-fold (Trx-fold) domain. The X-ray crystal structure of the Trx-fold domain of hPDCL2 was solved at 2.70 A resolution and resembled the Trx-fold domain of rat phosducin. Comparative structural analysis revealed the structural basis of their putative functional divergence.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Carrier Proteins / chemistry*
  • Crystallography, X-Ray
  • Humans
  • Nerve Tissue Proteins / chemistry*
  • Protein Folding*
  • Protein Structure, Tertiary
  • Rats
  • Thioredoxins / chemistry*

Substances

  • Carrier Proteins
  • Nerve Tissue Proteins
  • PDCL2 protein, human
  • Thioredoxins

Associated data

  • PDB/3EVIA
  • PDB/3EVIB